After learning that his terminally ill wife has six months to live, a man welcomes the support of his best friend who moves into their home to help out. His impact on the whole family is much greater than anyone could have imagined.

The Peanut Butter Falcon is an adventure story set in the world of a modern Mark Twain that begins when Zak, a young man with Down syndrome runs away from a nursing home where he lives to chase his dream of becoming a professional wrestler and attending the wrestling school of The Salt Water Redneck. Through circumstances beyond their control Tyler, a small time outlaw on the run becomes Zak's unlikely coach and ally. Together they wind through deltas, elude capture, drink whisky, find God, catch fish, and convince Eleanor, a kind nursing home employee with a story of her own to join them on their journey.

Disturbing and mysterious things begin to happen to a bartender in New Orleans after he picks up a phone left behind at his bar.